BioTek 405 TS - BioSPX

BioTek 405 TS

The gold standard in microplate washing with clog detection

Self-maintaining design prevents clogging and failure in the plate washer

Hands-off, self-testing technology

Information

The 405 TS Microplate Washer is the gold standard in microplate washing.

It features the patented Verify™ technology, which runs an automated QC check for manifold tube blockage, and visually reports any failed wells. The patented Ultrasonic Advantage™ can then be used to automatically and thoroughly clean the aspirate and dispense manifold. The 405 TS is the first self-checking, self-maintaining microplate washer available!

Cell-based assays and microsphere-based assays are easily run with the 405 TS’s unique set of available features and modules for gentle washing vacuum filtration and biomagnetic separation.

Patented Verify™ clog detection technology and Ultrasonic Advantage™
High resolution, advanced touch screen User Interface
USB flash drive ports for convenient file transfer and storage
Optimized for loosely adherent monolayers: low flow rates, angled dispensing

Features of the BioTek 405 TS Washer

Self-maintaining design with an ultrasonic bath prevents clogging and failure in the plate washer. The built-in, proprietary Ultrasonic Advantage allows the instrument to clean build up in the manifold tube automatically, without manual intervention.
Hands-off, self-testing Verify technology eliminates tedious manual procedures using an ultrasonic probe to check dispense and aspirate performance. Test results are automatically displayed and indicate when tubes may require additional cleaning.
Automated magnetic and filtration bead-based assays provide flexible operation in many applications. Variable wash steps and magnet accessories for biomagnetic separation workflows ensure high bead recovery. Vacuum filtration module is also available.
Cell-friendly design for high-quality results with angled dispense tubes, highly adjustable dispense, and aspiration rate settings for cell-based assays. The gentle flow rates and side-wall dispensing position ensure the integrity of cell monolayers.

How does the washer works?

Self-maintaining design with patented ultrasonic bath

Manifold tube clogs are the most common source of failure on plate washers. The built-in, patented Ultrasonic Advantage allows the instrument to clean build up in the manifold tube automatically, without removing it from the instrument.

Hands-off self-testing Verify technology option

The Verify technology option eliminates tedious manual procedures by using an ultrasonic probe to check dispense and aspirate performance. Test results are automatically displayed and indicate tubes that may require additional cleaning.

Automate magnetic and filtration bead-based assays

Multiplexed bead-based assays are very common, and 405 TS easily accommodates necessary wash steps. Magnet accessories for biomagnetic separation workflows, available in both flat and 4-zone ring designs, ensure high bead recovery. A vacuum filtration module is available for polystyrene bead assays.

Part #	384-well	96-well	Optimized Cell Washing	4-Buffer Switching	Ultrasonic Advantage	Verify™ technology	Biomagnetic Separation**	Vacuum Filtration**
405TSHT	•	*			•		•	•
405TSHTV	•	*		•	•		•	•
405TSU	•	•	•				•	•
405TSUV	•	•	•	•			•	•
405TSUS	•	•	•		•		•	•
405TSUSQ	•	•	•		•	•	•	•
405TSUVS	•	•	•	•	•		•	•
405TSUVSQ	•	•	•	•	•	•	•	•
405TSR		•					•	•
405TSRV		•		•			•	•
405TSRS		•			•		•	•
405TSRSQ		•			•	•	•	•
405TSRVS		•		•	•		•	•
405TSRVSQ		•		•	•	•	•	•

* 96-well washing available with optional manifold PN 1170010, sold separately** With available accessory module sold separately

405™ TS Microplate Washer Configurations
	Feature	Design
HT	Faster 384-well microplate washing	192-tube (16 x 12) manifold
		Dual-Action™
		HT Includes Ultrasonic Advantage
V	Automated Internal 4-Buffer Switching
S	Ultrasonic Advantage™	Built-in ultrasonic cleaner for manifold self-maintenance
U	96-/384-well microplate washing	96-tube (8 x 12) manifold
U	96-/384-well microplate washing	Dual-Action™
R	96-well microplate washing	96-tube (8 x 12) manifold
Q	Verify™ technology	Built-in clog detection for dispense and aspirate tubes

GENERAL
Microplate types	96- and 384-well
	Low profile and standard height
	Solid and filter bottom (option)
	Filter pore sizes from 0.45 µm to 1.2 µm
Onboard software	Create, edit or run multiple protocols
Software (computer control)	LHC2 pc software
	LHC2 Secure for 21 CFR Part 11 compliance (option)
	SiLA Compliant driver (option)
Separation	Biomagnetic separation, vacuum filtration (optional)
Shaking	Programmable up to 60 minutes
Shaking	Slow, medium, fast or variable
Soaking	Programmable up to 60 minutes
Ultrasonic Advantage™	Yes (option)
Verify™ clog detection	Yes (option)
Automation	BioStack and 3rd party automation compatible
Automation	BioSpa 8 Automated Incubator compatible
WASHING
Manifold types	96-well washing: 96-tube manifold – straight dispense tubes
	96- and 384-well washing: 96-tube Dual-Action manifold – 20° angled dispense tubes
	384-well washing (fast): 192-tube Dual-Action manifold – 7° angled dispense tubes
Volume range	25 – 3,000 µL/well, in 1 µL increments
Wash cycles	1 – 250
Buffer/reagent selection	Auto switching (internal) for up to 4 buffers (option)
Supply bottle	4 L or 10 L (optional)
Dispense precision	<3% CV: 300 µL/well (96-well washing)
Dispense precision	<4% CV: 80 µL/well (384-well washing)
Residual volume	< 2 µL/well (96- & 384-well plates)
Residual volume	96-tube manifold for 96 wells; 192-tube for 384 wells
Wash speed	96-wells, 300 µL/well, 3 cycles; <30 seconds
	384-wells,100 µL/well, 3 cycles: <80 seconds
	384-wells, 400 µL/well, 1 cycle: <20 seconds
Flow rates	High flow to low flow
Flow rates	Optimized rates for cell assays
Sterilization	Chemical
Vacuum filtration	Selectable: Approximate final at 30 seconds:
	Lowest: -38 mmHg
	Low: -113 mmHg
	Medium: -200 mmHg
	High: -390 mmHg
	Highest: -506 mmHg

	Vacuum filtration time range: 5 to 999 seconds
PHYSICAL CHARACTERISTICS
Power	100 – 240 Volts AC. 50/60 Hz
Dimensions	14″ W x 17″ D x 10″ H
Dimensions	(35.6 x 43.2 x 25.4 cm)
Weight	With internal buffer switching – 36 lbs (16.5 kg)
Weight	Without – 30 lbs (13.5 kg)
REGULATORY
Regulatory	CE and TUV marked. ROHS compliant. In Vitro Diagnostic use models are available.

The 405 TS has extensive onboard software, accessed through the convenient touchscreen interface. Program all aspects of the system’s wash and maintenance parameters, quickly and easily and store them onboard for routine use. LHC LHC Software allows computer-based programming of multi-step processes and it is used for integrating BioTek’s multi-mode washer dispensers, washers and dispensers into robotic systems. You can operate the system under computer control via LHC, or create protocols in LHC and download to the instrument for recall and execution. LHC Secure software LHC Secure software offers features to facilitate compliance to FDA directive 21 CFR Part 11 with computer control of BioTek’s Multi-Mode Washer Dispensers, Washers and Dispensers. LHC SiLA LHC SiLA software driver enables BioTek washer and dispenser integration into SiLA compliant automated systems. Includes LHC software for computer control and third party integration of BioTek’s Multi-Mode Washer Dispensers, Washers and Dispensers.

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Information

The 405 TS Microplate Washer is the gold standard in microplate washing.

Features of the BioTek 405 TS Washer

How does the washer works?

Self-maintaining design with patented ultrasonic bath

Hands-off self-testing Verify technology option

Automate magnetic and filtration bead-based assays

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