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Liberty 2.0

Short product description
A powerful entry-level peptide synthesizer.


The Liberty 2.0 is the next generation of the The Liberty Lite™ Microwave Peptide Synthesizer.

The entry-level system for CEM’s best in class microwave peptide synthesizer line. The Liberty 2.0 provides advantages over existing peptide synthesizers with it’s patented use of microwave irradiation during both the deprotection and coupling steps (12 minute cycle times), in-situ temperature control, Flex-Add™ delivery system, and efficient solvent usage.


  • 12 min Cycle Time
  • Flex-Add™ critical reagent delivery system (patented)
  • True Internal fiber-optic temperature control
  • 0.005 – 5 mmol scale range
  • 27 amino acid positions

Flex-Add Technology: The best way to deliver critical reagents.

  • Infinitely variable – deliver whatever volume you want (unlike sample loops)
  • No priming ever
  • No washing and less complex than syringe pumps



High Throughput (HT) Loaders : High-throughput peptide synthesis made easy.

  • Automated synthesis of 4 peptides (individual 20mer’s completed every 4 hours)
  • The Liberty 2.0 paired with the HT4 allows for automated synthesis of 4 peptides
  • Individual 20mer’s completed every 4 hours



The Microwave Advantage

Microwave energy brings more to peptide synthesis than a rapid change in temperature. Combined with microwave transparent reaction vessels, your reaction, not the vessel, is heated with a uniform, single mode energy distribution. Rapid kinetic movement caused by microwave energy accelerates the reaction and reduces aggregation.

  • Sythesizer comparison

    Pick the synthesizer that’s best for you

    Liberty 2.0Liberty Blue 2.0Liberty PRIME 2.0
    Cycle Time (at 0.1mmol)12 minutes4 minutes2.5 minutes
    System Waste (at 0.1mmol)32 mL16 mL10 mL
    Scale Range0.005 – 5 mmol0.005 – 5 mmol0.005 – 5 mmol
    Headspace FlushingNoYesYes
    Amino Acid Positions272730
    External Reagent Positions445
    RV CameraNoYesYes
    LED Visual FeedbackNoYesYes
    High-Throughput OptionsHT4HT4, HT12HT4, HT12, HT24
    Optional AccessoriesN/AN/AFull cGMP Compliance Package
  • The Liberty 2.0 Series

    The Liberty 2.0 Series feature significant advancements in peptide quality, robustness, and overall flexibility compared to the previous generation.

    A major advancement featured on the Liberty Blue 2.0 and Liberty PRIME 2.0 systems is the use of a new Headspace Flushing technology allowing for the synthesis of longer peptides by ensuring cleaner reaction vessel surfaces. Additionally, engineering improvements to the overall system fluidics and software provide increased robustness and flexibility. Learn more about the exciting updates to the most advanced peptide synthesizer line available.


View the Liberty 2.0 series brochure

Application notes

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Flexible, Powerful Software

The newly updated software is both flexible and easy to use, making sure nothing stands between you and your synthesis. Customize methods with unique monomers, orthogonal deprotection, branching, cyclizing, and more. Easily check on reactions on the run screen, where the run can be edited, paused, and resumed at any time.