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Agilent

BioTek EL406

Short product description
Microplate Washer Dispenser. Combines fast microplate washing with 3 reagent dispensers in 1 compact instrument

Information

The EL406 Combination Washer Dispenser offers fast, full plate washing along with three reagent dispensers in one, compact instrument. Its multiple capabilities include washing and dispensing for standard assays, plus biomagnetic separation and vacuum filtration protocols. The patented Dual-Action™ manifold optimizes washing for loosely adherent cell monolayers, while the patented Ultrasonic Advantage™ helps prevent blockages in the manifold tubes before washing, to reduce assay failure.

Syringe pump and peristaltic pump dispensers each offer unique advantages, and the EL406 offers both, along with superior plate washing, on a single platform – making the EL406 a workhorse for your laboratory.

  • Combines fast microplate washing with 3 reagent dispensers in 1 compact instrument
  • 96-, 384- and 1536-well plate compatible
  • Gentle processing for cell-based assays
  • Bead washing: magnetic and polystyrene
  • Easy maintenance with Ultrasonic Advantage™
  • Configurations

    Part #
    1536-/ 384-/ 96-well
    1536-/ 384-well
    1536-well
    384-/ 96-well
    384-well
    96-well
    3 reagent disp.
    2 reagent disp.
    1 reagent disp.
    406PSUB3SB
    406PSUB3LB
    406PSUB1SB
    406PSUB1LB
    406PSUB2SB
    406PSUB2LB
    406PSU0SB
    406PSU0LB
    406SNA0LB
    406PSUB3
    406PSUB1
    406PUB3
    406PUB1
    406PSUB2
    406PUB2
    406PSNA4
    406SNA4
    406P4

     

    EL406™ 1536-/384-/96-well Microplate Washer Dispenser Configurations
    FeatureDesign
    P1-Reagent Dispense Module –Autoclavable
    1 Peristaltic Pump8-tip (1 x 8) cassette
    Sapphire jeweled, steel or plastic tips
    S2-Reagent Dispense Module –Autoclavable
    2 Syringe Pumps2 16-tube (1 x 16) manifolds
    Steel tubes
    SNA2-Reagent Dispense Module –Non-autoclavable
    2 Syringe Pumps1 16-tube (2 x 8) manifolds – except with P/N 406SNA0-LB
    Steel tubes
    UWash Module – Ultrasonic Advantage™
    BWash Module – Automatic 4-Buffer Switching
    1Wash Module – 384-/96-well microplate washingDual-Action™
    96-tube (8 x 12) manifold
    Steel tubes
    2Wash Module – faster 384-well microplate washingDual-Action™
    192-tube (16 x 12) manifold
    Steel tubes
    3Wash Module – 384-/96-well microplate washingDual-Action™
    Interchangeable 96-tube (384-/96- well washing) and 192-tube (faster 384-well washing) manifolds
    Steel tubes
    4Wash Module – 96-well microplate washing96-tube (8 x 12) manifold
    Steel tubes
    SBWash Module – 1536-well microplate washing and dispensing2 32-tube (1 x 32) dispense manifolds
    Small bore, sapphire jeweled tubes
    128-tube (4 x 32) aspiration manifold
    LBWash Module – 1536-well microplate washing and dispensing2 32-tube (1 x 32) dispense manifolds
    Large bore, steel tubes
    128-tube (4 x 32) aspiration manifold
  • specifications

    GENERAL
    Microplate typesDispensing (peri pump and syringe)
    96-, 384- and 1536-well standard, deep and PCR plates; 6-. 12-, 24- and 48-well plates (dispense tip configurable)
    Washing
    96-. 384-well standard plates; 6-, 12-, 24-,and 48-well plates (with compatible manifold configuration)
    Onboard softwareCreate, edit or run multiple protocols
    Software (computer control)LHC2 Software
    LHC2 Secure for 21 CFR Part 11 compliance (option)
    SiLA Compliant driver (option)
    ShakingProgrammable up to 60 minutes
    Slow, medium, fast or variable
    SoakingProgrammable up to 60 minutes
    USB ports (2)For protocol storage/transfer and for optional external mouse or keyboard
    AutomationBioStack and 3rd party automation compatible
    BioSpa 8 Automated Incubator compatible
    WASHING
    Manifold types96- and 384-well washing: 8-tube manifold
    6-, 12-, 24-, 48-well washing: Custom manifolds available
    Volume range20-30,000 µL/well
    Wash cycles1-okt
    Supply bottle2 L
    Dispense accuracy3%
    Dispense precision96-/384-well plates, 300 µL/well: <3% CV
    6-well plates, 5560 µL/well: <5% CV
    Residual volume96-well plate, 300 µL/well: < 2 µL/well
    Wash speed96-wells, 8-tube manifold, 3 cycles, >300 µL/well: <130 seconds
    Wash volume20-30,000 µL/well
    Waste bottle2L
    Flow rates140-422 µL/well/second
    SterilizationChemical
    DISPENSING – PERISTALTIC PUMP (MULTI-CHANNEL)
    Manifold types1 x 8 – sapphire jeweled 316 SS, 316 SS or polypropylene tips, with 1, 5 or 10 µL tubing
    Fluid delivery1 or 2 peristaltic pumps
    Dispense speed96 wells, 5 µL cass, 10 µL/ well: 3 seconds
    96 wells, 5 µL cass, 20 µL/ well: 3.5 seconds
    384 wells, 5 µL cass, 5 µL/ well: 6.5 seconds
    384 wells, 10 µL cass, 10 µL/ well: 8 seconds
    384 wells, 1 µL cass, 1 µL/ well: 6 seconds
    1536 wells, 1 µL cass, 1 µL/ well: 21 seconds
    Volume range500 nL – 3,000 µL/well, selectable in 1 µL increments
    Flow ratesUser programmable rates from high to low
    Dispense performance1 µL cassette: recommended range: 1 – 50 µL
    Accuracy: +5% at 1 µL
    Precision: <5% CV at 1 µL
    <10% CV at 500 nL
    Minimum Prime Volume: 1.20 mL
    5 µL cassette: recommended range: 5 – 2,500 µL
    Accuracy: +2.0% at 5 µL
    Precision: <2.5% CV at 5 µL
    Minimum Prime Volume: 4.23 mL
    10 µL cassette: recommended range: 10 – 3,000 µL
    Dispense Accuracy: +2.0% at 10 µL
    Dispense Precision: <2.0% CV at 10 µL
    Minimum Prime Volume: 7.36 mL
    Recommended cassette replacement interval1 µL Cassette: 1,000 384-well microplates at 5 µL well
    5 µL Cassette: 1,000 96-well microplates at 50 µL well
    10 µL Cassette: 1,000 96-well microplates at 100 µL well
    SterilizationAutoclave, chemical
    DISPENSING – SYRINGE PUMP
    Manifold types96- and 384-well dispensing:
    One 16-tube (2 x 8) manifolds – 316 SS tubes
    Two 16-tube (1 x 16) manifolds – 316 SS tubes
    1536-well dispensing:
    Two 32-tube (1 x 32) manifolds – sapphire jeweled 316 SS or 316 SS tubes
    6- to 48-well dispensing: custom autoclavable manifolds available
    Fluid deliveryTwo positive displacement syringe drives
    Dispense speed20 µL /well, 96 wells, 1 x16 tubes:: 5 seconds
    20 µL /well, 384 wells, 1 x16 tubes:: 14 seconds
    3 µL /well, 1536 wells, 2 x 32 tubes:: 7 seconds
    Volume range3 – 3,000 µL/well selectable in 1 µL increments
    Minimum Prime Volume: 12 mL
    Flow ratesUser programmable rates from high to low
    Dispense accuracy+1 µL at 5 µL
    +1 µL at 20 µL
    +1% at 100 µL
    Dispense precision<5% CV at 5 µL
    <2.5% CV at 20 µL
    <1% CV at 100 µL
    Supply bottle1 L or 2 L
    SterilizationChemical, autoclavable option
    DISPENSING – PERISTALTIC PUMP (RAD TECHNOLOGY)
    Labware typesSingle tip: 6-, 12-, 24-, 48-, 96-, 384-well plates; low profile
    standard height and deep well formats; PCR trays and microtubes
    8-to-1 tip: 6-, 12-, and 24-well plates
    Manifold TypesRAD single, with plastic or steel tip with 1, 5 or 10 tubing, 7° angle
    RAD 8-to-1 plastic tip, with 5 µL tubing, angled bulk dispense chute
    Volume range500 nL – 30,000 µL
    Minimum prime volume1 µL cass, 18″: 90 µL ; 1 µL cass, 30″: 150 µL
    5 µL cass, 18″: 320 µL; 1 µL cass, 30″: 530 µL
    10 µL cass, 18″: 555 µL; 10 µL cass, 30″: 920 µL
    Dispense speed (high flow)1 µL cass, 1 µL/well: 19s (96 wells) 55s (384 wells)
    1 µL cass, 10 µL/well: 33s (96 wells), 112s (384 wells)
    5 µL cass, 5 µL/well: 19s (96 wells), 58s (384 wells)
    5 µL cass, 100 µL/well: 76s (96 wells), 286s (384 wells)
    10 µL cass, 10 µL/well: 21s (96 wells), 66s (384 wells)
    10 µL cass, 100 µL/well: 70s (96 wells), 259s (384 wells)
    Dispense performance1 µL cass (med), 0.5 µL/well: Precision 10% CV
    1 µL cass (med), 1 µL/well: Accuracy + 10%, Precision 10% CV
    1 µL cass (med), >2 µL/well: Accuracy + 5%, Precision 5% CV
    5 µL cass (high), 5 µL/well: Accuracy + 4%, Precision 5% CV
    5 µL cass (high), >10 µL/well: Accuracy + 2%, Precision 2.5% CV
    10 µL cass (high), 10 µL/well: Accuracy + 4%,Precision 4% CV
    10 µL cass (high), >20 µL/well: Accuracy + 2%, Precision 2 %CV
    8-to 1 cass(high), 40 µL/well: Accuracy + 4%
    8-to 1 cass (high), >10 µL/well: Precision 2.5%CV
    8- to 1cass(high), >80 µL/well: Accuracy + 2%
    PHYSICAL CHARACTERISTICS
    Power100 – 240 Volts AC. 50/60 Hz
    DimensionsBase instrument: 17.19″W x 11.75″ D x 8″ H (43.51 x 29.21 x 20.32 cm)
    WeightBase instrument:
    19.5 lbs (8.8 Kg)
    REGULATORY
    RegulatoryCE and TUV marked, RoHS Compliant. Models for In Vitro Diagnostic use are available.
  • Software

    The EL406 has extensive onboard software, with an intuitive menu-driven interface. Program all aspects of the system’s dispense, wash and maintenance parameters, quickly and easily. Up to 75 programs can be stored onboard.

    LHC
    LHC Software allows computer-based programming of multi-step processes and it is used for integrating BioTek’s multi-mode washer dispensers, washers and dispensers into robotic systems. You can operate the system under computer control via LHC, or create protocols in LHC and download to the instrument for recall and execution.

    LHC Secure software
    LHC Secure software offers features to facilitate compliance to FDA directive 21 CFR Part 11
    with computer control of BioTek’s Multi-Mode Washer Dispensers, Washers and Dispensers.

    LHC SiLA software
    LHC SiLA softwaredriver enables BioTek washer and dispenser integration into SiLA compliant automated systems. Includes LHC software for computer control and third party integration of BioTek’s Multi-Mode Washer Dispensers, Washers and Dispensers.

  • Features

    Combines fast microplate washing with 3 reagent dispensers in 1 compact instrument
    There’s no need for multiple instruments when you have an EL406 in the lab! The EL406 is microplate washer with peristaltic and syringe pump modules available to make it into an efficient multi-tasking system. For benchtop use or integrated into automated systems, the EL406 does the work of multiple instruments.

    96-, 384- and 1536-well plate compatible
    BioTek’s patented Dual-Action™ manifold quickly washes 96- and 384-well plates. For 1536 washing, unique aspirate and dispense manifolds rapidly dispense and aspirate across the plate. Wash speeds for the three plate types range from 13 seconds to 36 seconds, keeping all your processes efficient.

    Gentle processing for cell-based assays
    Cell-based assays can be challenging to wash – too often, cell monolayers are disrupted by vigorous dispensing or overly intense aspiration. The EL406 Dual-Action manifold and plate carrier have x-y-z adjustments, and flow rates are fully adjustable – to optimize parameters for even the most sensitive assays. Angled dispense tubes direct fluid flow to the well sides, further minimizing disruption.

    Bead washing: magnetic and polystyrene
    The EL406 is a powerhouse for many standard plate washing and dispensing protocols, but it also automates more complex operations like magnetic and polystyrene bead washing workflows – and it’s Luminex® xMap® approved. Bead washing is available for 96- and 384-well microplates.

    Easy maintenance with Ultrasonic Advantage™
    EL406 has a number of automated system maintenance features, including. BioTek’s patented Ultrasonic Advantage™. The dispense and aspirate tubes are immersed into the built-in ultrasonic bath in the priming trough while the automate cleaning program runs, dislodging and aspirating away salt crystal and protein buildup in the tubes.

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