Cell and Gene therapy

Our Xpertise for your Cell and gene therapy

We are dedicated to help CGT researchers with an array of next-gen cell analysis solutions in the Benelux

Cell and gene therapy are cutting-edge medical approaches that harness the power of our cells and genes to treat a disease. Both therapies aim to prevent, to treat or to cure a genetic disease, but cell and gene therapies work differently. We briefly explain this very complex matter below.

Gene Therapy

Gene therapy involves modifying or replacing faulty genes within the cells to correct a genetic disorder or disease.
This is often done by introducing a healthy copy of the gene into the patient’s cells, typically using a harmless virus as a delivery vehicle.
Once the corrected gene is inside the cell, it can start functioning properly, potentially curing a disease at its root cause

Cell therapy

Cell therapy involves using living cells, often stem cells, to replace or repair damaged tissues or organs in the body. Stem cells are special because they can generate different types of cells in the body, making them valuable for repairing or replacing damaged cells.
Cells are cultivated or modified outside the body before being injected into the patient.

How cell and gene therapies work together

Sometimes, cell and gene therapy are used together. For example using gene therapy to modify stem cells before they are used in cell therapy, ensuring they function properly once they are transplanted into the patient.

Benefits of cell and gene therapy

These therapies offer potentially curative treatments for diseases that were previously difficult or impossible to treat effectively.
They can also provide more targeted and personalized treatments, tailored to a patient’s specific genetic makeup.
Additionally, they have the potential to reduce the need for long-term medication or invasive procedures for some conditions.

In essence, cell and gene therapies represent exciting developments in medicine. BioSPX and Agilent are dedicated to help CGT researchers by providing an array of next-gen cell analysis solutions, including:

Immunophenotyping – Flow Cytometers

Expanded flexibility with up to 30-color options using 5 lasers.
Wide, 7-log dynamic range eliminates the need for routine detector adjustments.
Intuitive and powerful software for data acquisition, analysis, and reporting
Automation-ready capability for high throughput needs.

Novocyte

1 to 3 lasers

PMT

Up to 35 000 evts/sec

Up to 17 parameters

200 nm sensitivity

NovoCyte Advanteon

1 to 3 lasers

siPM

Up to 100.000 evts/sec

Up to 23 parameters

100 nm sensitivity

NovoCyte Quanteon

4 lasers (VBYR)

siPM

Up to 100.000 evts/sec

Up to 27 parameters

100 nm sensitivity

NovoCyte Penteon

5 lasers (VBYR + UV)

siPM

Up to 100.000 evts/sec

Up to 32 parameters

100 nm sensitivity

Immune cell monitoring – Real-Time Cell Analysis

xCELLigence SP, MP, HT: Provides non-invasive and label-free real-time cell analysis in 96 or 384 well formats.
xCELLigence eSight: Multiplex impedance-based data with live cell imaging for increased confidence.
Drive key insights and discoveries with specialized live cell analysis applications.

Cell imaging – Multimode Readers

Automated digital microscopy and conventional microplate detection in a configurable, upgradable platform.
Environmental controls for live cell imaging.
Hit picking–multimode detection and imaging saves time and data storage.

Cytation C10

Benchtop confocal imaging

Combination of spinning disk confocal and widefield imaging plus multimode reader

Air or water immersion and phase contrast objectives

Publication-quality images

Cytation 5 and BioSpa8 (automated incubator)

Advanced cell-level analysis including nuclear and cytoplasmic masks

Plate washing, media replacement and reagent injection

Complete workflow automation, sample prep to detection

Combined digital microscopy and multi-mode detection

Synergy Neo 2

Fast and high performing multi-mode microplate reader

Scientific quad monochromators with continuously variable bandwidth from 3 nm to 50 nm

Live cell assay optimized: CO2/O2 control, incubation to 65 °C and direct bottom illumination

Multiple PMTs including dual top PMTs for ultra-fast ratiometric assays

Cell and Gene therapy

Our Xpertise for your Cell and gene therapy

We are dedicated to help CGT researchers with an array of next-gen cell analysis solutions in the Benelux

Gene Therapy

Cell therapy

How cell and gene therapies work together

Benefits of cell and gene therapy

Immunophenotyping – Flow Cytometers

Novocyte

NovoCyte Advanteon

NovoCyte Quanteon

NovoCyte Penteon

Immune cell monitoring – Real-Time Cell Analysis

xCELLigence RTCA SP

xCELLigence RTCA MP

xCELLigence RTCA HT

xCELLigence RTCA eSight

Cell imaging – Multimode Readers

Cytation C10

Cytation 5 and BioSpa8 (automated incubator)

Synergy Neo 2

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