Randox Biosciences offer a comprehensive range of technologies and solutions to make immunology focused research become more efficient, cost effective and accurate. These technologies, coupled with Randox’s excellent support, ensure you receive consistent results with a high level of accuracy. We produce the majority of our products in-house and are much more flexible in terms of adapting to the methods of your research project. Therefore, whatever stage of the process you are in, be it biomarker identification studies right through to clinical trials, we can provide you with a full range of arrays, biomarkers and analysers that will best fit your individual requirements.
Randox Research offers a comprehensive range of technologies and solutions to make cardiovascular focused research become more efficient, cost effective and accurate. The Randox research division has over 60 cardiovascular and cerebrovascular biomarkers that can be custom picked to be assayed on the award winning Biochip Array Technology (BAT) array. Further to our multiplex offering the Randox Research division offers a unique lipid profile which combines conventional lipid assays with emerging biomarkers associated with cardiovascular disease as well as numerous other reagents available to aid cardiovascular studies.
Quality Results
• Inter and Intra-assay CV’s typically less than 10%
• Assays standardised to reference material where appropriate
• Excellent sensitivity, sub-pg/mL in many instances
• Assays validated to a clinical diagnostic standard
• Minimal batch variation, ideal for longitudinal research studies
Reduced Sample Volume
• Analyse a complete profile of biomarkers from as little as 25µl of sample
• Ideal when conservation of sample is critical
No Hidden Costs
• Full analyser package includes biochip imaging module, PC and imaging software, thermoshaker, biochip
carrier handling tray and barcode scanner
• Protein arrays: all inclusive kits including reagents, biochips, buffer and multi-analyte calibrators
Consolidation
• Consolidation of immunoassay and molecular diagnostics onto a single platform
Cytokines are small innate regulatory proteins involved in immune response and are produced by various cell types including B-cells, T-cells, macrophages, neutrophils, basophils, eosinophils and endothelial cells. Cytokines function as intercellular chemical messengers. They act as external controlling elements in hematopoiesis and also mediate and control immune and inflammatory responses. They have been implicated in pathological conditions such as cancer, cardiovascular disease, allergic response and play a significant role in surgery recovery, including transplantation.
• Similar functions can be stimulated by different cytokines.
• They can act synergistically or antagonistically therefore measuring a single cytokine
may miss an important facet of response progression
• Have duplicity of function when dealing with infection
• Can affect their host cell (autocrine), nearby cells (paracrine)or distant cells (endocrine)
• Commonly cascade so cytokine activation pathways can more readily be observed if many are measured
simultaneously
• Exert their influence through receptors in the cell membrane or within the cell
• Cytokine Array I
• Cytokine High Sensitivity Array
• Cytokine Array III
• Cytokine Array IV
• Cytokine Array V
To determine multiple cytokines in a single sample at a single time point, Randox offers a comprehensive menu of 33 cytokines, cytokine receptors and growth factors, over five multi-analyte arrays. Each cytokine assay is performed on a 9 x 9mm activated biochip with spatially discrete test regions containing antibodies specific to each of the analytes. The combination of highly specific antibodies and advanced chemistries enables cytokines, cytokine receptors and growth factors to be detected simultaneously in a single sample, providing valuable information relating to each cytokine under test and possible associations between cytokines in each sample
In some cases, the immune response over-reacts, turning cytokines against the body they are designed to protect. When the cytokine cascades fail to shut down, they can drive the host into a state of acute or chronically activated cells, which dominate an otherwise dormant immune system. Examples of the most obvious manifestations of this hypersensitivity are an unnecessary inflammatory response and fever; both of which can be life threatening if left untreated.
